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Most branches are only 1–2 glucose units long.",{"type":686,"children":865},[866],{"type":689,"value":867},"Here is an illustration of a fragment of the dextran structure: ",[],{"__typename":870,"id":871,"imageHeadline":6,"imageKontainer":872},"ImageBlockRecord","fcDN4w13QlO62SR1Hum1Ng",[873],{"url":874,"urlBaseName":875,"thumbnailUrl":876,"type":513,"extension":877,"description":489,"alt":489,"fileId":878,"fileName":879,"folderId":674,"token":489,"external":489,"cf":880,"downloadTemplateId":519,"originalWidth":881,"originalHeight":881,"originalSize":882},"https:\u002F\u002Fpharmacosmos.kontainer.com\u002Fcdn\u002FHFVLHfypoMLD\u002Fdextran-graph-09.png","https:\u002F\u002Fpharmacosmos.kontainer.com\u002Fcdn\u002FHFVLHfypoMLD\u002Fdextran-graph-09","https:\u002F\u002Fpharmacosmos.kontainer.com\u002Fcdn\u002FHFVLHfypoMLD\u002Fthumbnail\u002Ffullscreen\u002Fdextran-graph-09.jpg","png",19097908,"Dextran_Graph_09.png",[],880,52821,{"__typename":743,"id":884,"fullWidthLeftAligned":637,"bodyText":885},"bxsUZfbWSZqlQvDej_4TeQ",{"value":886,"links":897},{"schema":681,"document":887},{"type":683,"children":888},[889,893],{"type":754,"level":755,"children":890},[891],{"type":689,"value":892},"Physical Properties",{"type":686,"children":894},[895],{"type":689,"value":896},"Dextran fractions have a wide range of molecular sizes and display predictable physical behaviours. In solution, they exhibit stable viscosity and favourable osmotic properties, forming expandable coils that are suitable for various biological applications.",[],{"__typename":743,"id":899,"fullWidthLeftAligned":637,"bodyText":900},"CzPkBEZbRka-UvnEf-nYRg",{"value":901,"links":916},{"schema":681,"document":902},{"type":683,"children":903},[904,908,912],{"type":754,"level":755,"children":905},[906],{"type":689,"value":907},"Molecular size",{"type":686,"children":909},[910],{"type":689,"value":911},"The designation 5, 10, etc. represents the weight-average molecular weight divided by 1,000 Daltons. Thus Dextran 10 corresponds to a weight-average molecular weight of 10,000 Daltons.",{"type":686,"children":913},[914],{"type":689,"value":915},"The molecular dimensions of some dextran fractions are shown below.",[],{"__typename":870,"id":918,"imageHeadline":6,"imageKontainer":919},"cPYyJu8rR7C7WE0HpvInxQ",[920],{"url":921,"urlBaseName":922,"thumbnailUrl":923,"type":513,"extension":877,"description":489,"alt":489,"fileId":924,"fileName":925,"folderId":674,"token":489,"external":489,"cf":926,"downloadTemplateId":519,"originalWidth":927,"originalHeight":928,"originalSize":929},"https:\u002F\u002Fpharmacosmos.kontainer.com\u002Fcdn\u002FwnjUUi4lLE20\u002Fmolecular-dimensions.png","https:\u002F\u002Fpharmacosmos.kontainer.com\u002Fcdn\u002FwnjUUi4lLE20\u002Fmolecular-dimensions","https:\u002F\u002Fpharmacosmos.kontainer.com\u002Fcdn\u002FwnjUUi4lLE20\u002Fthumbnail\u002Ffullscreen\u002Fmolecular-dimensions.jpg",19069354,"Molecular dimensions.png",[],802,511,32021,{"__typename":743,"id":931,"fullWidthLeftAligned":637,"bodyText":932},"SDdii-hRQomp7caY1JdYnw",{"value":933,"links":1017},{"schema":681,"document":934},{"type":683,"children":935},[936,940,944,948,951,955,959,964,968,972,976,979,983,999,1003,1006,1010,1014],{"type":754,"level":755,"children":937},[938],{"type":689,"value":939},"Solubility",{"type":686,"children":941},[942],{"type":689,"value":943},"Dextran is highly soluble in water and various electrolyte solutions, with minimal pH dependency. Concentrated solutions (>50% w\u002Fv) can be prepared. It is also soluble in some organic solvents like DMSO, DMF, NMP, pyridine, formamide, ethylene glycol, and glycerol, but insoluble in monohydric alcohols and many ketones.",{"type":686,"children":945},[946],{"type":689,"value":947},"Note: Low MW dextran fractions (5 and 10) may form turbid solutions over time. Boiling the solution after preparation can delay this effect.",{"type":686,"children":949},[950],{"type":689,"value":752},{"type":754,"level":755,"children":952},[953],{"type":689,"value":954},"Filtration",{"type":686,"children":956},[957],{"type":689,"value":958},"Dextran solutions are easily filterable. However, for very viscous solution having either high concentration or high molecular weight, filtration may require larger filters and higher pressure. Raising the temperature can improve filtration efficiency.",{"type":686,"children":960},[961],{"type":689,"marks":962,"value":752},[963],"strong",{"type":754,"level":755,"children":965},[966],{"type":689,"value":967},"Stability",{"type":686,"children":969},[970],{"type":689,"value":971},"Dextran fractions are stable for over five years when stored in airtight containers at room temperature. They are hygroscopic and can absorb moisture if not properly sealed.",{"type":686,"children":973},[974],{"type":689,"value":975},"Dextran solutions are stable when sterilised via autoclaving and can be stored for extended periods at consistent temperatures. While pH 6–7 is ideal, stability is maintained between pH 4 and 10. Irradiation should be avoided, as it may degrade dextran.",{"type":686,"children":977},[978],{"type":689,"value":752},{"type":754,"level":755,"children":980},[981],{"type":689,"value":982},"Safety and Biocompatibility",{"type":686,"children":984},[985,987,997],{"type":689,"value":986},"Dextran has been used in human products for decades across IV, IM, oral, and topical applications. It holds a well-established safety profile and is classified as GRAS (",{"url":988,"meta":989,"type":993,"children":994},"https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcdrh\u002Fcfdocs\u002Fcfcfr\u002FCFRSearch.cfm?fr=582.1275",[990],{"id":991,"value":992},"target","_blank","link",[995],{"type":689,"value":996},"Generally Recognised As Safe",{"type":689,"value":998},") by the US FDA.",{"type":686,"children":1000},[1001],{"type":689,"value":1002},"Most safety studies focus on Dextran 40 and Dextran 70. Clinical use and long-standing biocompatibility make it a preferred choice in medicine. Dextran also demonstrates excellent tolerance in oral use and is included in products like Spasfon and Opalmon.",{"type":686,"children":1004},[1005],{"type":689,"value":752},{"type":754,"level":755,"children":1007},[1008],{"type":689,"value":1009},"Biodegradability",{"type":686,"children":1011},[1012],{"type":689,"value":1013},"Dextran is a naturally derived, biodegradable polysaccharide. In the body, smaller dextran molecules are eliminated renally, while larger molecules are broken down by dextranase in the liver or reticuloendothelial system into glucose and terminally into water and carbon dioxide. This dual elimination pathway is especially beneficial for patients with renal insufficiency.",{"type":686,"children":1015},[1016],{"type":689,"value":6},[],{"title":655,"description":1019,"noIndex":637,"twitterCard":489,"image":489},"This guide explores the molecular structure, physical behavior, and key properties of dextran. ",[1021,1024,1025,1028],{"text":1022,"disabled":637,"to":1023},"Home","\u002F",{"disabled":637,"text":34,"to":33},{"disabled":637,"text":1026,"to":1027},"The Science of Dextran","\u002Fdextran-insights\u002Fthe-science-of-dextran\u002F",{"disabled":641,"text":655,"to":1029},"\u002Fdextran-insights\u002Fthe-science-of-dextran\u002Fdextran-chemistry-properties\u002F",{"_site":1031},{"globalSeo":1032,"favicon":489},{"facebookPageUrl":6,"siteName":1033,"titleSuffix":6,"twitterAccount":489,"fallbackSeo":1034},"Pharmacosmos Dextran",{"twitterCard":1035,"title":1033,"noIndex":637,"description":1036,"image":489},"summary_large_image","Pharmacosmos Dextran fallback",{"value":1038,"links":1044},{"schema":681,"document":1039},{"type":683,"children":1040},[1041],{"type":686,"children":1042},[1043],{"type":689,"value":690},[],{"value":722,"links":1046},[],{"value":746,"links":1048},[],{"value":886,"links":1050},[],{"value":901,"links":1052},[],{"value":933,"links":1054},[],1789715967340]