Dextran biocompatibility

For more than half a century, dextrans have been used clinically, providing us with impressive proof of their safety and quality. Most safety studies have been related to parenterally administered dextran solutions in the molecular weight range of 40,000 (Dextran 40) to 70,000 (Dextran 70). The intravenous mean lethal dose of Dextran 70 fraction is 55 g/kg bodyweight in mice, 18 g/kg bodyweight in rabbits, and 10 g/kg bodyweight in dogs. Dextran may be ingested orally and is well tolerated, as the ingestion of dextran is followed by a rapid increase in blood sugar and liver glycogen.

Over the years, many other applications of dextran in medicine have contributing to its excellent record of biocompatibility. Dextran is an ingredient in ophthalmic solutions, creams and ointments and it is used for intrauterine examinations.

Pharmacosmos manufactures Pharmaceutical Quality Dextran, including Dextran 1, Dextran 40, Dextran 60, and Dextran 70 according to pharmacopeial specifications (e.g., EP, USP, and JP).