When dextran is used in a pharmaceutical product or medical device, it should always be of pharmaceutical quality.

Technical Quality Dextran is a high purity dextran fraction with selected average molecular weights and molecular weight distributions used as starting or intermediate reagents.

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Ultra Narrow

Dextran Ultra is a range of very narrow, dispersed Dextran fractions with polydispersity Mw/Mn below 1.5. This makes our Dextran Ultra highly suitable for characterization, complexing and other pharmaceutical/technical uses where added/increased/additional requirements with regard to narrow distributions and quality are required.

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Standards & GPC Standards

Our Standards comes with a complete set of specifications including; weight average molecular weight (Mw), number average molecular weight (Mn), and mean peak molecular weight (Mp)

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Derivatives

Pharmacosmos offer Dextran derivatives with the same high standard and requirements to the highest quality as our world-leading Dextran products.

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Applications

As a nontoxic and biocompatible polysaccharide, dextran is used widely in research and production in the pharmaceutical, biomedical, and life science industries.

Vaccines

Dextran can be part of vaccines as a carrier, a back-bone and/or as a stabilizer of the antigen or other subunits. Derivatives of dextran such as DEAE-dextran are commonly used.

Dextran in vaccines

Dextrans are often used in vaccines is as stabilizers or excipients. They help to maintain integrity and potency during storage and transportation, and they can provide protection against degradation while maintaining the proper pH and preventing the aggregation of vaccine components. In addition, dextrans can be used as carriers or delivery systems for vaccine antigens. Conjugating or encapsulating antigens with dextrans can enhance the stability and immunogenicity of the antigens, and dextrans can also protect antigens from degradation, improve their solubility, and facilitate their uptake by immune cells. This can potentially enhance the immune response and improve the efficacy of the vaccine.

In the development of controlled-release vaccine delivery systems, dextrans are modified to form nanoparticles or hydrogels that enable antigens to be released in a controlled manner over an extended period, potentially optimising the immune response and reducing the number of doses required.