Hydrogenated dextran, or Hydrodextran, is a chemically modified dextran where the terminal glucose residue undergoes reduction, converting its aldehyde group (typically present as a hemiacetal) into an alcohol. This transformation turns the terminal glucose into sorbitol (hence the name Polyglucose sorbitol), enhancing the dextran's stability and altering its chemical properties for specific applications.

Hydrogenated dextran (or Dextranol), due to its chemical stability, is an ideal starting material for many dextran derivatives, especially those requiring modification of alcohol groups. This stability enhances its versatility in producing specialised derivatives for various applications, such as conjugates and nanoparticles, particularly in environments where redox stability is crucial. It is especially useful in drug formulations, preventing unwanted interactions between aldehydes (from dextran) and amines (from proteins, neurotransmitters, or drugs). By eliminating the hydrogenation step, hydrogenated dextran reduces the need for specialised equipment, streamlining production and improving process efficiency.

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