Pharmacosmos Hydrogenated Dextran
Hydrogenated Dextran (also known as Hydrodextran, reduced dextran, Polyglucose sorbitol, Isodextrol, and Dextranol) differs from regular dextran as it is non-reducing. The hydrogenation process produces a carbohydrate that retains most of the physical properties of the original dextran but is chemically more stable and inert.
Pharmacosmos Hydrogenated Dextran is based on our world-leading dextran products and produced at our state-of-the-art, GMP-approved facility in Denmark.
Unique structure offering enhanced stability
Hydrogenated dextran, or Hydrodextran, is a chemically modified dextran where the terminal glucose residue undergoes reduction, converting its aldehyde group (typically present as a hemiacetal) into an alcohol. This transformation turns the terminal glucose into sorbitol (hence the name Polyglucose sorbitol), enhancing the dextran's stability and altering its chemical properties for specific applications.
Use of hydrogenated dextran
Hydrogenated dextran (or Dextranol), due to its chemical stability, is an ideal starting material for many dextran derivatives, especially those requiring modification of alcohol groups. This stability enhances its versatility in producing specialised derivatives for various applications, such as conjugates and nanoparticles, particularly in environments where redox stability is crucial. It is especially useful in drug formulations, preventing unwanted interactions between aldehydes (from dextran) and amines (from proteins, neurotransmitters, or drugs). By eliminating the hydrogenation step, hydrogenated dextran reduces the need for specialised equipment, streamlining production and improving process efficiency.
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