Pharmacosmos Polyaldehyde Dextran
Polyaldehyde Dextran (PAD) - also known as dextran polyaldehyde, dextran dialdehyde, dialdehyde dextran, and oxidized dextran - is a modified form of dextran, where aldehyde groups (—CHO) are introduced along its polymer chain. These reactive aldehyde groups enable polyaldehyde dextran to form covalent bonds with molecules, especially primary amines found in proteins, peptides, and other biomolecules. This reactivity makes polyaldehyde dextran valuable for a variety of scientific and medical applications.
Pharmacosmos Polyaldehyde Dextran is based on our world-leading dextran products and produced at our state-of-the-art, GMP-approved facility in Denmark.
Enhanced reactivity
The aldehyde groups in polyaldehyde dextran (also called oxidized dextran) allow it to form covalent bonds with primary amines, which are commonly found in proteins, peptides, and other biomolecules. This ability to form stable Schiff base linkages makes dialdehyde dextran highly effective for bioconjugation, enabling the attachment of biomolecules like enzymes, antibodies, and drugs. Additionally, its reactivity allows for cross-linking with other polymers, facilitating hydrogel formation that is valuable in tissue engineering and wound healing.
Versatile applications of polyaldehyde dextran
Polyaldehyde dextran (also referred to as dextran polyaldehyde) has diverse applications, including bioconjugation for creating targeted drug delivery systems and biosensors. Its ability to cross-link with other materials makes it suitable for hydrogel formation, used in tissue engineering, drug delivery, and wound healing. The aldehyde groups also enable the immobilization of biomolecules on solid surfaces, such as in biosensors and diagnostic assays. In drug delivery, polyaldehyde dextran allows controlled release of therapeutic agents, improving targeting and efficacy. Additionally, it is used to modify medical device surfaces, enhancing biocompatibility and attaching bioactive molecules.
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