Why Dextran Matters in Eye Drop Innovation

Dextran is a versatile, glucose-based polysaccharide widely used in pharmaceutical formulations—including ophthalmic applications. In eye drops, dextran plays an important role in improving hydration, comfort, and drug performance. This guide explores the properties, benefits, applications, and future potential of dextran in eye care.

What is Dextran?

Dextran is a high-molecular-weight polysaccharide produced by bacterial fermentation of sucrose, typically using Leuconostoc mesenteroides. It is composed primarily of glucose units linked by α-1,6-glycosidic bonds with occasional α-1,3 branches. Known for its biocompatibility and viscosity-enhancing properties, dextran is well-suited for use in eye drop formulations.

Key Properties of Dextran in Eye Drops

• Biocompatibility: Non-toxic and well-tolerated by ocular tissues, making it ideal for sensitive applications like the eye.

• Viscosity Enhancer: Increases the residence time of eye drops on the ocular surface, enhancing hydration and drug delivery.

• Water Solubility: Fully water-soluble, allowing easy formulation into clear, stable aqueous eye drops.

• Stabilisation: Can help stabilise other active ingredients, improving shelf life and performance.

Benefits of Dextran in Ophthalmic Use

1. Moisturising Relief: Alleviates symptoms of dry eye by retaining moisture and reducing evaporation.

2. Prolonged Contact Time: Enhances efficacy by maintaining longer contact with the eye surface.

3. Formulation Stability: Improves stability of both the solution and the active pharmaceutical ingredients.

4. Contact Lens Compatibility: Provides added comfort and lubrication for contact lens wearers.

Possible Limitations

• Allergic Reactions: Rare, but possible in sensitive individuals. Symptoms may include redness, itching, or mild swelling.

• Temporary Blurring: The viscous nature of dextran can cause short-lived visual blurring after application.

Primary Use Cases

• Dry Eye Syndrome: Lubricating and hydrating properties make dextran eye drops effective in treating mild to moderate dry eye symptoms.

• Post-Surgical Recovery: Helps reduce irritation and maintain moisture following ocular surgery.

• Contact Lens Discomfort: Used to rehydrate lenses and improve wearability.

• Excipient in Combination Formulas: Supports active ingredients in multi-agent eye drops for

Dextrans Commonly Used in Ophthalmic Solutions

·         Dextran 40 pharmaceutical quality

·         Dextran 60 pharmaceutical quality

·         Dextran 70 pharmaceutical quality

·         Dextran 500 pharmaceutical quality

Recent Developments & Innovation

Recent advances in biotechnology and formulation science have led to the development of dextran derivatives with improved adhesion and bioavailability for ophthalmic use. Research is ongoing into smart delivery systems using dextran to enable controlled drug release and extended duration of action in the eye.

To sum-up, Dextran is a well-established ingredient in eye care formulations, valued for its safety, hydration, and stabilising benefits. Its role in dry eye treatment, post-surgical support, and contact lens care continues to grow. As ophthalmic formulation science evolves, dextran is expected to remain a key component in innovative and effective eye drop solutions.

Frequently Asked Questions (FAQ)

What is Dextran in eye drops?
A plant-derived polysaccharide used to improve moisture retention, viscosity, and formulation stability in eye drops.

Is Dextran safe for eye use?
Yes. Dextran is widely recognised for its biocompatibility and is used in numerous over-the-counter and prescription ophthalmic products.

Can Dextran cause side effects?
Some users may experience mild allergic reactions or temporary blurred vision due to its viscosity-enhancing properties. These effects are usually short-lived.

Are Dextran eye drops suitable for contact lens wearers?
Yes. Dextran is often included in rewetting drops and is known to improve comfort for contact lens users.

Can Dextran stabilise other ingredients in eye drops?
Yes. Dextran can help maintain the integrity and performance of active ingredients by providing a stable aqueous environment.