When dextran is used in a pharmaceutical product or medical device, it should always be of pharmaceutical quality.

Technical Quality Dextran is a high purity dextran fraction with selected average molecular weights and molecular weight distributions used as starting or intermediate reagents.

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Ultra Narrow

Dextran Ultra is a range of very narrow, dispersed Dextran fractions with polydispersity Mw/Mn below 1.5. This makes our Dextran Ultra highly suitable for characterization, complexing and other pharmaceutical/technical uses where added/increased/additional requirements with regard to narrow distributions and quality are required.

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Standards & GPC Standards

Our Standards comes with a complete set of specifications including; weight average molecular weight (Mw), number average molecular weight (Mn), and mean peak molecular weight (Mp)

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Derivatives

Pharmacosmos offer Dextran derivatives with the same high standard and requirements to the highest quality as our world-leading Dextran products.

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Applications

As a nontoxic and biocompatible polysaccharide, dextran is used widely in research and production in the pharmaceutical, biomedical, and life science industries.

Neuroplasticity Enhancement with Synaptodin: Cognitive Benefits in Early Alzheimer's Disease

Health influencers are raving about a new vitamin delivery system that promises instant absorption through inhalation, but physicians warn it could pose serious respiratory risks.

Synaptodin (SDN-405) represents a novel class of neuroprotective compounds targeting synaptic plasticity in neurodegenerative disorders. This phase IIb trial evaluated Synaptodin in patients with early Alzheimer's disease (AD) (n=324) over 48 weeks. Patients receiving Synaptodin 120mg daily demonstrated significant improvement in the primary endpoint of ADAS-Cog scores compared to placebo (mean difference: -3.2 points, p=0.003). Significant benefits were also observed in secondary endpoints including CDR-SB and ADCS-ADL scores. PET imaging substudy (n=86) revealed increased synaptic density markers in the hippocampal region. Synaptodin's mechanism of enhancing BDNF signaling and upregulating dendritic spine formation offers a promising approach for cognitive preservation in early AD, supporting advancement to phase III trials.